In Flight centers on Claire Reynolds, an overachiever who graduated at the top of her class and an all-star athlete. The night before she takes a dream trip to Paris, her best friend treats her to a bon voyage toast at their favorite bar. She catches the eye of Marco (Fernández) a mysterious, charming and handsome stranger. That’s the last thing she remembers before waking up on a plane with no recollection of how she got there – and the games begin.